Patients and their families should be informed of the presumed high risk of cancer of between 10-15%.
During basic diagnostics, the risk of congenital tumors should always be borne in mind. With regard to skeletal, neurological, and renal abnormalities, such diagnostics should include spinal, abdominal, and pelvic imaging.
In patients with severe symptoms, determining the tumor markers AFP and β-HCG may well be helpful in addition to a basic blood analysis.
For milder progressions, regularly determining AFP and β-HCG and conducting regular abdominal and pelvic ultrasounds should be considered as well.