{"id":27092,"date":"2024-05-26T11:54:39","date_gmt":"2024-05-26T09:54:39","guid":{"rendered":"https:\/\/www.krebs-praedisposition.de\/?post_type=kompendium&p=27092"},"modified":"2025-08-22T15:15:16","modified_gmt":"2025-08-22T13:15:16","slug":"bap1-dependent-tumor-predisposition-syndrome","status":"publish","type":"kompendium","link":"https:\/\/www.krebs-praedisposition.de\/en\/kompendium\/bap1-dependent-tumor-predisposition-syndrome\/","title":{"rendered":"BAP1-Dependent Tumor Predisposition Syndrome"},"content":{"rendered":"

BAP1-Dependent Tumor Predisposition Syndrome \u2013\u00a0Definition<\/h2><\/div>
<\/div><\/div><\/div><\/div>

BAP1-dependent tumor predisposition syndrome (OMIM; 614327) describes a cancer predisposition syndrome that can lead to a variety of malignant neoplasms. These neoplasms include uveal and malignant melanomas, malignant mesotheliomas, and renal cell carcinomas.<\/p>\n<\/div>

Synonym:<\/p>\n<\/div><\/div><\/div>

BAP1-TPDS<\/p>\n<\/div><\/div><\/div><\/div>

<\/div><\/div>
<\/div><\/div>

Gene:<\/p>\n<\/div><\/div><\/div>

BAP1<\/em> = BRCA1-associated protein-1<\/p>\n<\/div><\/div><\/div><\/div>

Gene \u00adproduct:<\/p>\n<\/div><\/div><\/div>

Repair proteins<\/p>\n<\/div><\/div><\/div><\/div>

<\/div><\/div>

Function:<\/p>\n<\/div><\/div><\/div>

Tumor suppressor gene<\/p>\n<\/div><\/div><\/div><\/div>

<\/div><\/div>

Pattern of inheritance: <\/p>\n<\/div><\/div><\/div>

Autosomal dominant<\/p>\n<\/div><\/div><\/div><\/div>

<\/div><\/div>

Prevalence:<\/p>\n<\/div><\/div><\/div>

Subject of current research<\/p>\n<\/div><\/div><\/div><\/div>

<\/div><\/div>

Genotype-phenotype correlation:<\/p>\n<\/div><\/div><\/div>

Subject of current research<\/p>\n<\/div><\/div><\/div><\/div>

<\/div><\/div>

Penetrance:<\/p>\n<\/div><\/div><\/div>

Subject of current research<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

<\/div>
<\/div><\/div><\/div><\/div><\/div><\/div>

Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>