{"id":28100,"date":"2024-10-29T15:09:09","date_gmt":"2024-10-29T14:09:09","guid":{"rendered":"https:\/\/www.krebs-praedisposition.de\/?post_type=kompendium&p=28100"},"modified":"2025-08-26T10:12:07","modified_gmt":"2025-08-26T08:12:07","slug":"carney-complex","status":"publish","type":"kompendium","link":"https:\/\/www.krebs-praedisposition.de\/en\/kompendium\/carney-complex\/","title":{"rendered":"Carney Complex"},"content":{"rendered":"

Carney Complex \u2013\u00a0Definition<\/h2><\/div>
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The Carney complex (CNC) describes a rare cancer predisposition syndrome that leads to the development of characteristic pigment spots, multiple myxomas, hormonal tumors or regulatory disorders, and malignant neoplasms.<\/p>\n<\/div>

Synonyms:<\/p>\n<\/div><\/div><\/div>

Familial myxoma syndrome, Carney syndrome<\/p>\n<\/div><\/div><\/div><\/div>

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Gene:<\/p>\n<\/div><\/div><\/div>

PRKAR1A<\/em> (protein kinase A-regulating subunit 1\u03b1)<\/p>\n<\/div><\/div><\/div><\/div>

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Gene product:<\/p>\n<\/div><\/div><\/div>

PRKAR1A<\/p>\n<\/div><\/div><\/div><\/div>

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Function:<\/p>\n<\/div><\/div><\/div>

Tumor suppressor gene<\/p>\n<\/div><\/div><\/div><\/div>

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Pattern of inheritance:<\/p>\n<\/div><\/div><\/div>

Autosomal dominant<\/p>\n<\/div><\/div><\/div><\/div>

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Prevalence:<\/p>\n<\/div><\/div><\/div>

Approximately 750 patients with CNC are recorded worldwide; the prevalence is unknown.<\/p>\n<\/div><\/div><\/div><\/div>

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Genotype-phenotype correlation:<\/p>\n<\/div><\/div><\/div>

Unknown<\/p>\n<\/div><\/div><\/div><\/div>

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Penetrance:<\/p>\n<\/div><\/div><\/div>

70-80 %<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

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Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>