{"id":30645,"date":"2026-07-16T13:50:33","date_gmt":"2026-07-16T11:50:33","guid":{"rendered":"https:\/\/www.krebs-praedisposition.de\/?post_type=kompendium&p=30645"},"modified":"2026-07-17T06:41:21","modified_gmt":"2026-07-17T04:41:21","slug":"multiple-endocrine-neoplasia-type-5","status":"publish","type":"kompendium","link":"https:\/\/www.krebs-praedisposition.de\/en\/kompendium\/multiple-endocrine-neoplasia-type-5\/","title":{"rendered":"Multiple Endocrine Neoplasia Type 5"},"content":{"rendered":"

Multiple Endocrine Neoplasia Type 5 \u2013\u00a0Definition<\/h2><\/div>
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Multiple endocrine neoplasia type 5 (MEN5) is a genetic disorder caused by a pathogenic germline mutation in the MAX gene (MYC-associated factor X). It primarily predisposes individuals to adrenomedullary pheochromocytoma. Less commonly, extra-adrenal tumors or tumors originating from the neural crest are described.<\/p>\n<\/div>

Synonym:<\/p>\n<\/div><\/div><\/div>

MAX-associated MEN syndrome<\/p>\n<\/div><\/div><\/div><\/div>

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Gene:<\/p>\n<\/div><\/div><\/div>

MAX gene (MYC-associated factor X)<\/p>\n<\/div><\/div><\/div><\/div>

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Gene \u00adproduct:<\/p>\n<\/div><\/div><\/div>

MAX protein<\/p>\n<\/div><\/div><\/div><\/div>

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Function:<\/p>\n<\/div><\/div><\/div>

MAX encodes a transcription factor involved in cell proliferation, differentiation, apoptosis, and angiogenesis.<\/p>\n<\/div><\/div><\/div><\/div>

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Pattern of inheritance:<\/p>\n<\/div><\/div><\/div>

Autosomal dominant<\/p>\n<\/div><\/div><\/div><\/div>

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Prevalence:<\/p>\n<\/div><\/div><\/div>

currently unknown<\/p>\n<\/div><\/div><\/div><\/div>

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Genotype-phenotype correlation:<\/p>\n<\/div><\/div><\/div>

no clearly established correlation to date<\/p>\n<\/div><\/div><\/div><\/div>

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Penetrance:<\/p>\n<\/div><\/div><\/div>

not yet definitively defined<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

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Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>