\"APC-Associated Adenomatous Polyposis\" \u2013\u00a0What is It?<\/h2><\/div>
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APC-associated adenomatous polyposis comprises three diseases based on pathogenic variants, or genetic changes, in the APC<\/em> gene. These are familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP) and gastric carcinoma with proximal polyposis (gastric adenocarcinoma and proximal polyposis of the stomach, GAPPS).<\/p>\n
In FAP, hundreds to thousands of polyps (mucosal protrusions) usually appear in adolescence and are localised in the gastrointestinal tract, most commonly in the colon. These polyps can degenerate and lead to malignant diseases such as bowel cancer. There is also an increased risk of developing other benign and malignant tumours.<\/p>\n
AFAP is a variant of FAP with significantly fewer polyps and a later onset of cancer.<\/p>\n
GAPPS is characterised by a large number of polyps in the stomach and an increased risk of stomach cancer. The bowel is rarely affected.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>
Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>
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APC-Associated Adenomatous Polyposis \u2013 What Is It? (This Section)<\/div><\/li><\/ul><\/div><\/div>