The diagnosis is made clinically by an expert experienced in syndromes. A point system is used. If the score is \u2265 4 points, a classic BWS is clinically present; if the score is \u2265 2 points, genetic diagnostics should be performed.<\/p>\n<\/div>
Main Criteria (2 points per symptom)<\/h4><\/div><\/div><\/div>
\n- Large tongue<\/li>\n
- Umbilical hernia<\/li>\n
- One-sided tall stature<\/li>\n
- Multiple\/bi-lateral Wilms’ tumors (these are kidney tumors) or so-called nephroblastomatosis<\/li>\n
- Elevated insulin levels<\/li>\n
- Special pathological findings of the adrenal gland, placenta, pancreas (adrenocortical cytomegaly, placental mesenchymal dysplasia, pancreatic adenomatosis)<\/li>\n<\/ul>\n<\/div>
Secondary Criteria (1 point per symptom)<\/h4><\/div>