\"Hereditary Pheochromocytoma\/Paraganglioma Syndromes\" \u2013\u00a0What Is It?<\/h2><\/div>
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Hereditary pheochromocytoma\/paraganglioma syndromes (HPP) are diseases caused by pathogenic variants, i.e., genetic changes in an SDH<\/em> gene, the MAX<\/em> gene, or the TMEM127<\/em> gene. They are characterized by mostly benign tumors that develop from precursor cells of the nerve cells of the involuntary nervous system. These so-called pheochromocytomas and paragangliomas can occur in the area of the brain, neck, or upper thoracic cavity and do not usually produce hormones. If they happen in the lower thoracic cavity, abdomen, or pelvis, the tumors generally release hormones (e.g., adrenaline and\/or noradrenaline). There is also an increased risk of tumors of the stomach, kidneys, and thyroid gland.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>
Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>
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Hereditary Pheochromocytoma\/Paraganglioma Syndromes \u2013 What Is It? (This Section)<\/div><\/li><\/ul><\/div><\/div>