LFS can be diagnosed clinically based on classic diagnostic criteria. There are also personal and familial constellations in which it makes sense to arrange genetic testing for the presence of LFS. Such a genetic test and the detection of a pathogenic TP53<\/em> variant confirm the diagnosis of LFS.<\/p>\n<\/div>Classic Diagnostics<\/h4><\/div><\/div><\/div>
Juvenile polyposis syndrome is suspected if the following findings are present:<\/p>\n
\n- Lack of red blood cells, bleeding of the rectum, polyps emerging from the rectum<\/li>\n
- >1 juvenile polyp (“juvenile” always refers to the histology of the polyps)<\/li>\n
- \u22651 juvenile polyp and JPS in the family<\/li>\n<\/ul>\n<\/div>
Diagnostic Criteria<\/h4><\/div>