{"id":25267,"date":"2024-02-26T16:15:17","date_gmt":"2024-02-26T15:15:17","guid":{"rendered":"https:\/\/www.krebs-praedisposition.de\/?post_type=lexikon&p=25267"},"modified":"2025-07-14T11:43:46","modified_gmt":"2025-07-14T09:43:46","slug":"multiple-endocrine-neoplasia-type-4","status":"publish","type":"lexikon","link":"https:\/\/www.krebs-praedisposition.de\/en\/lexikon\/multiple-endocrine-neoplasia-type-4\/","title":{"rendered":"Multiple Endocrine Neoplasia Type 4"},"content":{"rendered":"
\"Multiple Endocrine Neoplasia Type 4\" \u2013\u00a0What Is It?<\/h2><\/div>
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Multiple endocrine neoplasia type 4 (MEN4) is a genetic, i.e., inherited, disease caused by genetic changes in the CDKN1B<\/em> gene. Affected individuals have a significantly increased risk of developing parathyroid tumors associated with hyperparathyroidism (PHPT) and tumors of the anterior pituitary neuroendocrine tumors (PitNET). MEN4 is, therefore, clinically similar to multiple endocrine neoplasia type 1 (MEN1). In addition, benign tumors of the kidney (angiomyolipomas), hormone-active tumors of the gastrointestinal tract and pancreas, and tumors of the uterus, adrenal glands, and thyroid gland can occur.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>
Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>
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Multiple Endocrine Neoplasia Type 4 \u2013 What Is It? (This Section)<\/div><\/li><\/ul><\/div><\/div>