{"id":27000,"date":"2024-05-13T14:44:59","date_gmt":"2024-05-13T12:44:59","guid":{"rendered":"https:\/\/www.krebs-praedisposition.de\/?post_type=lexikon&#038;p=27000"},"modified":"2025-07-25T11:57:03","modified_gmt":"2025-07-25T09:57:03","slug":"peutz-jeghers-syndrome","status":"publish","type":"lexikon","link":"https:\/\/www.krebs-praedisposition.de\/en\/lexikon\/peutz-jeghers-syndrome\/","title":{"rendered":"Peutz-Jeghers Syndrome"},"content":{"rendered":"<p><div id=\"was-ist-das\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:180;--awb-padding-top:25px;--awb-padding-bottom:75px;--awb-padding-top-medium:25px;--awb-padding-bottom-medium:75px;--awb-padding-top-small:0px;--awb-padding-bottom-small:40px;--awb-background-color:var(--awb-color1);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:40px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column fusion-content-nowrap\"><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">\"Peutz-Jeghers Syndrome\" \u2013\u00a0What Is It?<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:0px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-flex-align-self-stretch\" style=\"--awb-overflow:hidden;--awb-bg-image:url(&#039;https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2022\/08\/FIT_BILD_Familie-in-KPS-Ambulanz.jpg&#039;);--awb-bg-position:center top;--awb-bg-size:cover;--awb-box-shadow:0px 0px 10px 10px rgba(0,0,0,0.15) inset;;--awb-border-color:var(--awb-custom16);--awb-border-top:5px;--awb-border-right:5px;--awb-border-bottom:5px;--awb-border-left:5px;--awb-border-style:solid;--awb-border-radius:50px 50px 50px 50px;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:30px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-center fusion-content-layout-column fusion-column-has-bg-image\" data-bg-url=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2022\/08\/FIT_BILD_Familie-in-KPS-Ambulanz.jpg\"><div class=\"fusion-separator fusion-no-medium-visibility fusion-no-large-visibility fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:200px;width:100%;\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-flex-align-self-stretch\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:3;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-center fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1 fusion-text-no-margin\" style=\"--awb-content-alignment:left;--awb-font-size:var(--awb-typography4-font-size);--awb-line-height:var(--awb-typography4-line-height);--awb-letter-spacing:var(--awb-typography4-letter-spacing);--awb-text-transform:var(--awb-typography4-text-transform);--awb-text-font-family:var(--awb-typography4-font-family);--awb-text-font-weight:var(--awb-typography4-font-weight);--awb-text-font-style:var(--awb-typography4-font-style);\"><p>Peutz-Jeghers syndrome (PJS) is a disease caused by <span data-teams=\"true\">pathogenic variants<\/span>, i.e., genetic changes in the <em>STK11<\/em> gene. The appearance of polyps in the gastrointestinal tract and typical pigment spots on the skin and mucous membranes characterize it. There is also an increased risk of cancer.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:170;--awb-background-color:var(--awb-color1);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-padding-top:50px;--awb-padding-right:10%;--awb-padding-bottom:30px;--awb-padding-left:10%;--awb-padding-bottom-medium:20px;--awb-padding-top-small:40px;--awb-padding-right-small:20px;--awb-padding-bottom-small:10px;--awb-padding-left-small:20px;--awb-overflow:hidden;--awb-bg-color:#f4fbff;--awb-bg-color-hover:#f4fbff;--awb-bg-size:cover;--awb-border-radius:3px 3px 0px 0px;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:0px;--awb-margin-left-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-no-medium-visibility fusion-no-large-visibility\" style=\"--awb-padding-top-small:0px;--awb-padding-right-small:20px;--awb-padding-bottom-small:20px;--awb-padding-left-small:20px;--awb-overflow:hidden;--awb-bg-image:linear-gradient(180deg, #f4fbff 0%,#e7f6ff 100%);--awb-bg-size:cover;--awb-border-radius:0px 0px 0px 3px;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:0px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:0px;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-one-page-text-link\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom15);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom15);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-1 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Peutz-Jeghers Syndrome \u2013 What Is It? (This Section)<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-one-page-text-link fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#diagnose\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-2 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">How Is \"Peutz-Jeghers Syndrome\" Diagnosed?<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-2 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#krebsrisiko\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-3 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">What Is the Risk of Cancer?<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-3 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#entstehung\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-4 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">What Is Known About the Development of \"Peutz-Jeghers Syndrome\"<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-4 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#therapie\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-5 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Is There Any Treatment Available?<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-5 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#frueherkennung\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-6 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Medical Measures for Early Detection<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-6 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#selbsthilfe\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-7 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#selbsthilfe\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-7 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Peutz-Jeghers Syndrome \u2013  What You Can Do Yourself<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-8 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#weitere-informationen\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-size:16px;--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:27.2px;--awb-icon-width:27.2px;--awb-icon-height:27.2px;--awb-icon-margin:11.2px;--awb-content-margin:38.4px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:14.08px;\" class=\"fusion-checklist fusion-checklist-8 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Links and Further Information (e.g., From Support Groups)<\/div><\/li><\/ul><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-5 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-no-small-visibility\" style=\"--awb-padding-right:5%;--awb-padding-bottom:50px;--awb-padding-left:10%;--awb-padding-right-medium:20px;--awb-padding-bottom-medium:30px;--awb-padding-left-medium:40px;--awb-overflow:hidden;--awb-bg-image:linear-gradient(180deg, #f4fbff 0%,#e7f6ff 100%);--awb-bg-size:cover;--awb-border-radius:0px 0px 0px 3px;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:0px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:0px;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-9 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-one-page-text-link\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom15);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom15);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-9 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Peutz-Jeghers Syndrome \u2013 What Is It? (This Section)<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-10 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-one-page-text-link fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#diagnose\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-10 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">How Is \"Peutz-Jeghers Syndrome\" Diagnosed?<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-11 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#krebsrisiko\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-11 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">What Is the Risk of Cancer?<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-12 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-one-page-text-link fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#diagnose\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-12 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">What Is Known About the Development of \"Peutz-Jeghers Syndrome\"?<\/div><\/li><\/ul><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-6 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-no-small-visibility\" style=\"--awb-padding-right:10%;--awb-padding-bottom:50px;--awb-padding-left:5%;--awb-padding-right-medium:40px;--awb-padding-bottom-medium:30px;--awb-padding-left-medium:20px;--awb-overflow:hidden;--awb-bg-image:linear-gradient(180deg, #f4fbff 0%,#e7f6ff 100%);--awb-bg-size:cover;--awb-border-radius:0px 0px 3px 0px;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:0px;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:0px;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-13 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#therapie\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-13 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Is There Any Form of Treatment Available?<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-14 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#frueherkennung\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-14 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Medical Measures for Early Detection<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-15 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#selbsthilfe\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-15 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Peutz-Jeghers Syndrome \u2013 What You Can Do Yourself<\/div><\/li><\/ul><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-16 fusion_builder_column_inner_1_1 1_1 fusion-flex-column fusion-column-inner-bg-wrapper\" style=\"--awb-inner-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><span class=\"fusion-column-inner-bg hover-type-none\"><a class=\"fusion-column-anchor\" href=\"#weitere-informationen\"><span class=\"fusion-column-inner-bg-image\"><\/span><\/a><\/span><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-row fusion-content-nowrap\"><ul style=\"--awb-iconcolor:var(--awb-color1);--awb-textcolor:var(--awb-custom10);--awb-line-height:30.6px;--awb-icon-width:30.6px;--awb-icon-height:30.6px;--awb-icon-margin:12.6px;--awb-content-margin:43.2px;--awb-circlecolor:var(--awb-custom10);--awb-circle-yes-font-size:15.84px;\" class=\"fusion-checklist fusion-checklist-16 fusion-checklist-default type-icons\"><li class=\"fusion-li-item\" style=\"\"><span class=\"icon-wrapper circle-yes\"><i class=\"fusion-li-icon fa-arrow-alt-down fas\" aria-hidden=\"true\"><\/i><\/span><div class=\"fusion-li-item-content\">Links (e.g., From Support Groups) and Further Information<\/div><\/li><\/ul><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"diagnose\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container has-pattern-background has-mask-background hundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:160;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-bottom:0px;--awb-padding-left:0px;--awb-margin-top:-55px;--awb-margin-top-medium:-25px;--awb-margin-top-small:-25px;--awb-background-color:var(--awb-color1);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-overflow:hidden;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-17 fusion_builder_column_inner_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator bigtriangle fusion-section-separator-1\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:75px;--awb-spacer-height-medium:75px;--awb-divider-height-small:50px;--awb-spacer-height-small:50px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-triangle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(231,246,255,1)\"><path d=\"M-1 -1 L50 99 L101 -1 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"diagnose\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container has-pattern-background has-mask-background hundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:150;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-bottom:0px;--awb-padding-left:0px;--awb-background-color:var(--awb-color1);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-overflow:hidden;--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:-30px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-color1);border-color:var(--awb-color1);border-top-width:50px;\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"diagnose\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:140;--awb-margin-top:-50px;--awb-margin-bottom:-50px;--awb-margin-top-medium:-25px;--awb-margin-bottom-medium:-50px;--awb-margin-top-small:-25px;--awb-margin-bottom-small:-50px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator bigtriangle fusion-section-separator-2\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:75px;--awb-spacer-height-medium:75px;--awb-divider-height-small:50px;--awb-spacer-height-small:50px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-triangle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(255,255,255,1)\"><path d=\"M-1 -1 L50 99 L101 -1 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-6 fusion-flex-container has-pattern-background has-mask-background fusion-parallax-none nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-background-position:center bottom;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:130;--awb-padding-top:150px;--awb-padding-bottom:100px;--awb-padding-top-medium:125px;--awb-padding-bottom-medium:80px;--awb-padding-top-small:100px;--awb-padding-bottom-small:75px;--awb-background-image:url(&quot;https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2022\/04\/FIT_HG_Gentapete-hellgrau-EF-Verlauf-04.jpg&quot;);--awb-background-size:cover;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-10 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:50px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:20px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-3 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">How Is \"Peutz-Jeghers Syndrome\" Diagnosed?<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:0px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-11 fusion_builder_column_1_3 1_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:33.333333333333%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:5.76%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:-15px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-margin-right-small:20%;--awb-margin-bottom-small:25px;--awb-margin-left-small:20%;--awb-max-width:300px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Diagnose.png\" alt class=\"img-responsive wp-image-26581\" srcset=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Diagnose-200x200.png 200w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Diagnose-400x400.png 400w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Diagnose-600x600.png 600w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Diagnose-800x800.png 800w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Diagnose.png 1000w\" sizes=\"(max-width: 1299px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-12 fusion_builder_column_2_3 2_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:66.666666666667%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.88%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:2.88%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:2.56%;--awb-spacing-left-medium:2.56%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-4 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Suspected Diagnosis<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:40px;\"><p>Peutz-Jeghers syndrome is suspected when the following findings are present<\/p>\n<ul>\n<li>\u22652 Peutz-Jeghers syndrome (PJS) type polyps in the gastrointestinal tract<\/li>\n<li>Characteristic dark blue to dark brown pigment patches on the skin or mucous membranes.<\/li>\n<li>Enlargement of the mammary gland in men due to oestrogen-producing testicular tumours<\/li>\n<li>e.g., intussusception (invagination of one bowel segment into another), especially in children or young adults<\/li>\n<\/ul>\n<\/div><div class=\"fusion-title title fusion-title-5 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Genetic Diagnostics<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:40px;\"><p>The diagnosis of Peutz-Jeghers syndrome is confirmed by detecting a <span data-teams=\"true\">pathogenic variant<\/span>, a genetic change in the <em>STK11<\/em> gene.<\/p>\n<\/div><div class=\"fusion-title title fusion-title-6 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Diagnostic criteria<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-4 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:-20px;\"><p>The diagnosis of &#8220;Peutz-Jeghers syndrome&#8221; is confirmed by genetic evidence of a <span data-teams=\"true\">pathogenic variant<\/span> of the <em>STK11<\/em> gene or one of the following findings:<\/p>\n<ul>\n<li>\u22652 histologically confirmed polyps of the PJS type<\/li>\n<li>Any number of PJS-type polyps in a person with at least one close relative with PJS<\/li>\n<li>Characteristic dark blue to dark brown pigmentation on skin or mucous membranes in a person with at least one close relative with PJS<\/li>\n<li>Any number of PJS-type polyps in a person with characteristic dark blue to dark brown pigmentation<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div id=\"krebsrisiko\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-7 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:120;--awb-margin-top:-50px;--awb-margin-bottom:0px;--awb-margin-top-medium:-25px;--awb-margin-bottom-medium:0px;--awb-margin-top-small:-25px;--awb-margin-bottom-small:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-13 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator bigtriangle fusion-section-separator-3\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:75px;--awb-spacer-height-medium:75px;--awb-divider-height-small:50px;--awb-spacer-height-small:50px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-triangle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(239,239,239,1)\"><path d=\"M-1 -1 L50 99 L101 -1 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-8 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:110;--awb-padding-top:100px;--awb-padding-bottom:100px;--awb-padding-top-medium:75px;--awb-padding-bottom-medium:100px;--awb-padding-top-small:50px;--awb-padding-bottom-small:75px;--awb-background-color:var(--awb-color1);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-14 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:50px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:20px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-7 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">What Is the Risk of Cancer?<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-15 fusion_builder_column_1_3 1_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:33.333333333333%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:5.76%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:-15px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-margin-right-small:20%;--awb-margin-bottom-small:25px;--awb-margin-left-small:20%;--awb-max-width:300px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img decoding=\"async\" width=\"1000\" height=\"1000\" title=\"FIT_ICON-LEXIKON_Krebsrisiko\" src=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsrisiko.png\" alt class=\"img-responsive wp-image-21081\" srcset=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsrisiko-200x200.png 200w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsrisiko-400x400.png 400w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsrisiko-600x600.png 600w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsrisiko-800x800.png 800w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsrisiko.png 1000w\" sizes=\"(max-width: 1299px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-16 fusion_builder_column_2_3 2_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:66.666666666667%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.88%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:2.88%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:2.56%;--awb-spacing-left-medium:2.56%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-5 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:40px;\"><p>Peutz-Jeghers syndrome is characterized by the common occurrence of polyps in the gastrointestinal tract and a typical dark blue to dark brown pigmentation on the skin and mucous membranes. The risk of cancer in and outside the gastrointestinal tract is significantly increased.<\/p>\n<\/div><div class=\"fusion-title title fusion-title-8 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Cancer Diseases<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-6 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:20px;\"><p>Below are the risk and average age of onset for the cancers known to be associated with Peutz-Jeghers syndrome.<\/p>\n<\/div>\n<div class=\"table-1\">\n<div class=\"table-1\">\n<table width=\"100%\">\n<thead>\n<tr>\n<th align=\"left\">Place of manifestation<\/th>\n<th align=\"left\">Risk<\/th>\n<th align=\"left\">Age of manifestation<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td align=\"left\">Large intestine<\/td>\n<td align=\"left\">39%<\/td>\n<td align=\"left\">42 &#8211; 46 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Stomach<\/td>\n<td align=\"left\">29%<\/td>\n<td align=\"left\">30 &#8211; 40 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Small intestine<\/td>\n<td align=\"left\">13%<\/td>\n<td align=\"left\">37 &#8211; 42 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Chest<\/td>\n<td align=\"left\">32% &#8211; 54%<\/td>\n<td align=\"left\">37 &#8211; 59 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Ovary<\/td>\n<td align=\"left\">21%<\/td>\n<td align=\"left\">28 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Cervix<\/td>\n<td align=\"left\">10%<\/td>\n<td align=\"left\">34 &#8211; 40 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Uterus<\/td>\n<td align=\"left\">9%<\/td>\n<td align=\"left\">43 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Pancreas<\/td>\n<td align=\"left\">11% &#8211; 36 %<\/td>\n<td align=\"left\">51 &#8211; 52 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Testicles<\/td>\n<td align=\"left\">9 %<\/td>\n<td align=\"left\">6 &#8211; 9 years<\/td>\n<\/tr>\n<tr>\n<td align=\"left\">Lung<\/td>\n<td align=\"left\">7% &#8211; 17 %<\/td>\n<td align=\"left\">47 years<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n<div class=\"fusion-title title fusion-title-9 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-top:40px;--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Polyps<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-7 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:40px;\"><p>Polyps can occur throughout the gastrointestinal tract but are most common in the small intestine. They can also occur outside the gastrointestinal tract (renal pelvis, urinary bladder, ureter, lungs, nose, and gall bladder). The malignant potential is still unknown. Polyps can cause complications such as intestinal obstructions, rectal prolapse, or severe gastrointestinal bleeding. The average age at which the first symptoms appear is 10 years; the first removal of polyps (polypectomy) is performed on average at the age of 13.<\/p>\n<\/div><div class=\"fusion-title title fusion-title-10 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Mucocutaneous Pigmentation<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-8 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:40px;\"><p>The characteristic dark blue to dark brown pigmentation spots rarely present at birth and usually develops by age 5. The pigmentation fades during puberty and adulthood. They tend to appear around the mouth, on the eyes and nostrils, on the cheek mucosa, and around the anal region. Pigment spots on the fingers are also common. There is no cancer risk associated with these characteristic pigmentations.<\/p>\n<\/div><div class=\"fusion-title title fusion-title-11 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Gonadal Tumors<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:28px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-9 fusion-text-no-margin\" style=\"--awb-text-transform:none;\"><p>Female PJS patients have an increased risk of ovarian and fallopian tube tumors. These usually occur on both sides and are benign.<\/p>\n<p>Male PJS patients have an increased risk of testicular tumors. These are tumors that can release estrogen and are usually benign.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div id=\"entstehung\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-9 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:100;--awb-margin-top:-50px;--awb-margin-bottom:-50px;--awb-margin-top-medium:-25px;--awb-margin-bottom-medium:-50px;--awb-margin-top-small:-25px;--awb-margin-bottom-small:-50px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-17 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator bigtriangle fusion-section-separator-4\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:75px;--awb-spacer-height-medium:75px;--awb-divider-height-small:50px;--awb-spacer-height-small:50px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-triangle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(255,255,255,1)\"><path d=\"M-1 -1 L50 99 L101 -1 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-10 fusion-flex-container has-pattern-background has-mask-background fusion-parallax-none nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-background-position:center bottom;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:90;--awb-padding-top:150px;--awb-padding-bottom:100px;--awb-padding-top-medium:125px;--awb-padding-bottom-medium:100px;--awb-padding-top-small:100px;--awb-padding-bottom-small:75px;--awb-background-image:url(&quot;https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2022\/04\/FIT_HG_Gentapete-hellgrau-EF-Verlauf-04.jpg&quot;);--awb-background-size:cover;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-18 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:50px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:20px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-12 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">What Is Known About the Development of \"Peutz-Jeghers Syndrome\" ?<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-19 fusion_builder_column_1_3 1_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:33.333333333333%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:5.76%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:-15px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-margin-right-small:20%;--awb-margin-bottom-small:25px;--awb-margin-left-small:20%;--awb-max-width:300px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-3 hover-type-none\"><img decoding=\"async\" width=\"1000\" height=\"1000\" title=\"FIT_ICON-LEXIKON_Krebsentstehung\" src=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsentstehung.png\" alt class=\"img-responsive wp-image-21075\" srcset=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsentstehung-200x200.png 200w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsentstehung-400x400.png 400w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsentstehung-600x600.png 600w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsentstehung-800x800.png 800w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Krebsentstehung.png 1000w\" sizes=\"(max-width: 1299px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-20 fusion_builder_column_2_3 2_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:66.666666666667%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.88%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:2.88%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:2.56%;--awb-spacing-left-medium:2.56%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-10 fusion-text-no-margin\"><p>Peutz-Jeghers syndrome is caused by a <span data-teams=\"true\">pathogenic variant<\/span>, i.e., a genetic change in the <em>STK11<\/em> gene. This gene codes for the STK11 protein, which acts as a tumor suppressor to ensure that the development of tumor cells is suppressed. If the <em>STK11<\/em> gene is present in an altered form, the STK11 protein is no longer produced correctly and, therefore, cannot function as a tumor suppressor.\u00a0This leads to the development of polyps and tumors.<\/p>\n<p>Peutz-Jeghers syndrome is usually passed on from parents to their children. The inheritance is autosomal dominant. The remaining cases (around 25%) are due to a spontaneous or new <span data-teams=\"true\">pathogenic variant<\/span>, known as a de novo mutation.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div id=\"therapie\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-11 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:80;--awb-margin-top:-50px;--awb-margin-bottom:0px;--awb-margin-top-medium:-25px;--awb-margin-bottom-medium:0px;--awb-margin-top-small:-25px;--awb-margin-bottom-small:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-21 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator bigtriangle fusion-section-separator-5\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:75px;--awb-spacer-height-medium:75px;--awb-divider-height-small:50px;--awb-spacer-height-small:50px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-triangle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(239,239,239,1)\"><path d=\"M-1 -1 L50 99 L101 -1 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-12 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-background-position:center bottom;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:70;--awb-padding-top:100px;--awb-padding-bottom:125px;--awb-padding-top-medium:75px;--awb-padding-bottom-medium:100px;--awb-padding-top-small:50px;--awb-padding-bottom-small:75px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-22 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:50px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:20px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-13 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">Is There Any Form of Treatment Available?<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-23 fusion_builder_column_1_3 1_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:33.333333333333%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:5.76%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:-15px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-margin-right-small:20%;--awb-margin-bottom-small:25px;--awb-margin-left-small:20%;--awb-max-width:300px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img decoding=\"async\" width=\"1000\" height=\"1000\" title=\"FIT_ICON-LEXIKON_Therapie\" src=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Therapie.png\" alt class=\"img-responsive wp-image-21077\" srcset=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Therapie-200x200.png 200w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Therapie-400x400.png 400w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Therapie-600x600.png 600w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Therapie-800x800.png 800w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/02\/FIT_ICON-LEXIKON_Therapie.png 1000w\" sizes=\"(max-width: 1299px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-24 fusion_builder_column_2_3 2_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:66.666666666667%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.88%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:2.88%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:2.56%;--awb-spacing-left-medium:2.56%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-11 fusion-text-no-margin\"><p>Polyps with a size of &gt;1cm should be removed as a precautionary measure to prevent subsequent complications and reduce the risk of transformation into a malignant tumor.<\/p>\n<p>Cancer should be treated according to the appropriate protocols.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-13 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-sizes-top:10px;--awb-border-color:var(--awb-custom10);--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:60;--awb-padding-top:50px;--awb-padding-bottom:30px;--awb-padding-top-small:60px;--awb-padding-bottom-small:60px;--awb-background-image:linear-gradient(180deg, var(--awb-custom14) 0%,var(--awb-custom15) 100%);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-stretch fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-25 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-no-medium-visibility fusion-no-large-visibility\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-14 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-text-color:var(--awb-color1);--awb-margin-bottom-small:5px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">Diagnosis of \" Peutz-Jeghers Syndrome\" What's Next?<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:40px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-color1);border-color:var(--awb-color1);border-top-width:5px;\"><\/div><\/div><div class=\"fusion-text fusion-text-12 fusion-text-no-margin\" style=\"--awb-content-alignment:center;--awb-text-transform:none;--awb-text-color:var(--awb-color1);--awb-margin-right:10%;\"><p>If you have been diagnosed with this cancer predisposition syndrome, it is important to see a specialist. The following section explains whether cancer screening tests or other measures are needed and how they should be carried out. We also give you some valuable tips on what you can do yourself. If you have any questions, please do not hesitate to contact us or your doctor.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-26 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-no-small-visibility\" style=\"--awb-padding-top:20px;--awb-padding-right:50px;--awb-padding-bottom:20px;--awb-bg-size:cover;--awb-border-color:var(--awb-color1);--awb-border-top:0;--awb-border-right:2px;--awb-border-bottom:0;--awb-border-left:0;--awb-border-style:solid;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:0px;--awb-margin-bottom-large:0px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:0px;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-center fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-15 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"--awb-text-color:var(--awb-color1);--awb-margin-left:10%;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:0px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-right\" style=\"margin:0;\">Diagnosis of \"Peutz-Jeghers Syndrome\" What's Next?<\/h2><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-27 fusion_builder_column_1_2 1_2 fusion-flex-column fusion-no-small-visibility\" style=\"--awb-padding-top:20px;--awb-padding-bottom:20px;--awb-padding-left:50px;--awb-bg-size:cover;--awb-border-color:var(--awb-color1);--awb-border-top:0;--awb-border-right:0;--awb-border-bottom:0;--awb-border-left:2px;--awb-border-style:solid;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:0px;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:0px;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-center fusion-content-layout-column\"><div class=\"fusion-text fusion-text-13 fusion-text-no-margin\" style=\"--awb-content-alignment:left;--awb-text-transform:none;--awb-text-color:var(--awb-color1);--awb-margin-right:10%;\"><p>If you have been diagnosed with this cancer predisposition syndrome, it is important to see a specialist. The following section explains whether cancer screening tests or other measures are needed and how they should be carried out. We also give you some valuable tips on what you can do yourself. If you have any questions, please do not hesitate to contact us or your doctor.<\/p>\n<\/div><\/div><\/div><\/div><\/div><div id=\"frueherkennung\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-14 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:50;--awb-margin-top:-50px;--awb-margin-bottom:0px;--awb-margin-top-medium:-25px;--awb-margin-bottom-medium:0px;--awb-margin-top-small:-25px;--awb-margin-bottom-small:0px;--awb-background-color:#f3f4f1;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-28 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator bigtriangle fusion-section-separator-6\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:75px;--awb-spacer-height-medium:75px;--awb-divider-height-small:50px;--awb-spacer-height-small:50px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-triangle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(58,79,92,1)\"><path d=\"M-1 -1 L50 99 L101 -1 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-15 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-background-position:center bottom;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:40;--awb-padding-top:100px;--awb-padding-bottom:50px;--awb-padding-top-medium:75px;--awb-padding-bottom-medium:75px;--awb-padding-top-small:50px;--awb-padding-bottom-small:75px;--awb-margin-bottom:0px;--awb-background-image:linear-gradient(180deg, #f3f4f1 0%,var(--awb-custom16) 100%);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-29 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-margin-bottom-medium:50px;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:20px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-16 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">Medical Measures for Early Detection<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-30 fusion_builder_column_1_3 1_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:33.333333333333%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:5.76%;--awb-width-medium:25%;--awb-order-medium:0;--awb-spacing-right-medium:7.68%;--awb-spacing-left-medium:7.68%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:-15px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element \" style=\"text-align:center;--awb-margin-right-small:20%;--awb-margin-bottom-small:25px;--awb-margin-left-small:20%;--awb-max-width:300px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-5 hover-type-none\"><img decoding=\"async\" width=\"1000\" height=\"1000\" src=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Frueherkennung.png\" alt class=\"img-responsive wp-image-26582\" srcset=\"https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Frueherkennung-200x200.png 200w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Frueherkennung-400x400.png 400w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Frueherkennung-600x600.png 600w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Frueherkennung-800x800.png 800w, https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_ICON-LEXIKON_Frueherkennung.png 1000w\" sizes=\"(max-width: 1299px) 100vw, (max-width: 640px) 100vw, 600px\" \/><\/span><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-31 fusion_builder_column_2_3 2_3 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:66.666666666667%;--awb-margin-top-large:0px;--awb-spacing-right-large:2.88%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:2.88%;--awb-width-medium:75%;--awb-order-medium:0;--awb-spacing-right-medium:2.56%;--awb-spacing-left-medium:2.56%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-14 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:20px;\"><p>The\u00a0<a href=\"https:\/\/aacrjournals.org\/clincancerres\/article\/30\/20\/4566\/748802\/Pediatric-Cancer-Screening-in-Hereditary\">AACR 2024 guidelines<\/a> recommend following specific surveillance measures:<\/p>\n<\/div><div class=\"fusion-title title fusion-title-17 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Gastrointestinal Tract<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-15 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:20px;\"><ul>\n<li>Gastroscopy, video capsule endoscopy, or magnetic resonance enterography and colonoscopy at 8 years\n<ul>\n<li>Polyps present \u2192 repeat every 2-3 years<\/li>\n<li>No polyps \u2192 repeat at 18 years<\/li>\n<\/ul>\n<\/li>\n<li>Families should be educated to recognize the signs and symptoms of intussusception and to seek urgent care promptly is essential when these signs and symptoms are observed\n<ul>\n<li>Intussusception is a medical condition where one part of the intestine folds into another part of the intestine, much like how a telescope slides into itself. This can cause a blockage, preventing food and fluids from passing through the digestive system. It can also reduce blood supply to the affected area, leading to severe complications if not treated promptly.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div><div class=\"fusion-title title fusion-title-18 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Gonads, Breast, Ovaries, Uterus and Cervix<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-16 fusion-text-no-margin\" style=\"--awb-text-transform:none;\"><ul>\n<li>Annual physical examination to check for precocious puberty in girls from childhood<\/li>\n<li>Annual gynaecological examination with ultrasound and serum CA 125 measurement from 18-20 years of age<\/li>\n<li>Annual breast cancer screening from the age of 25<\/li>\n<li>For boys: annual testicular examination and monitoring of body growth and body image<\/li>\n<\/ul>\n<\/div><div class=\"fusion-title title fusion-title-19 fusion-sep-none fusion-title-text fusion-title-size-four\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Pancreas<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:#939ea6;border-color:#939ea6;border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-17\"><ul>\n<li>Magnetic resonance imaging and ultrasound every 1-2 years from the age of 30<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-16 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:30;--awb-margin-top:0px;--awb-margin-bottom:-95px;--awb-margin-bottom-medium:-50px;--awb-margin-bottom-small:-25px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-32 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-section-separator section-separator big-half-circle fusion-section-separator-7\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:50px;--awb-spacer-height-medium:50px;--awb-divider-height-small:25px;--awb-spacer-height-small:25px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-half-circle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(228,230,223,1)\"><path d=\"M0 0 C55 180 100 0 100 0 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"selbsthilfe\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-17 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:20;--awb-padding-top:0px;--awb-padding-right:0px;--awb-padding-bottom:0px;--awb-padding-left:0px;--awb-margin-bottom:-100px;--awb-margin-bottom-medium:-50px;--awb-margin-bottom-small:-25px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-33 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-color1);border-color:var(--awb-color1);border-top-width:5px;\"><\/div><\/div><div class=\"fusion-section-separator section-separator big-half-circle fusion-section-separator-8\" style=\"--awb-spacer-height:100px;--awb-svg-margin-left:1.92%;--awb-svg-margin-right:1.92%;--awb-svg-margin-left-medium:1.92%;--awb-svg-margin-right-medium:1.92%;--awb-svg-margin-left-small:1.92%;--awb-svg-margin-right-small:1.92%;--awb-divider-height:100px;--awb-spacer-padding-top:inherit;--awb-divider-height-medium:50px;--awb-spacer-height-medium:50px;--awb-divider-height-small:25px;--awb-spacer-height-small:25px;--awb-sep-padding:0;--awb-svg-padding:0;\"><div class=\"fusion-section-separator-svg\"><svg class=\"fusion-big-half-circle-candy\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" version=\"1.1\" width=\"100%\" height=\"100\" viewBox=\"0 0 100 100\" preserveAspectRatio=\"none\" fill=\"rgba(255,255,255,1)\"><path d=\"M0 0 C55 180 100 0 100 0 Z\"><\/path><\/svg><\/div><div class=\"fusion-section-separator-spacer\"><div class=\"fusion-section-separator-spacer-height\"><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-18 fusion-flex-container has-pattern-background has-mask-background fusion-parallax-none nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-background-position:center bottom;--awb-background-repeat:repeat-x;--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:10;--awb-padding-top:200px;--awb-padding-bottom:150px;--awb-padding-top-medium:125px;--awb-padding-bottom-medium:75px;--awb-padding-top-small:100px;--awb-padding-bottom-small:100px;--awb-background-color:#d2e3ef;--awb-background-image:url(&quot;https:\/\/www.krebs-praedisposition.de\/wp-content\/uploads\/2023\/03\/FIT_HG_Was-Sie-selber-tun-koennen.jpg&quot;);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1456px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-34 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:60px;--awb-spacing-left-large:5.76%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:40px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-20 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-two\" style=\"--awb-margin-right:10%;--awb-margin-bottom:10px;--awb-margin-left:10%;--awb-margin-bottom-small:5px;--awb-margin-top-medium:0px;--awb-margin-right-medium:0px;--awb-margin-bottom-medium:10px;--awb-margin-left-medium:0px;\"><h2 class=\"fusion-title-heading title-heading-center\" style=\"margin:0;\">Peutz-Jeghers Syndrome \u2013 What You Can Do Yourself<\/h2><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:0px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom10);border-color:var(--awb-custom10);border-top-width:5px;\"><\/div><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-35 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:5.76%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:11.52%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:5.76%;--awb-margin-bottom-medium:50px;--awb-spacing-left-medium:3.6864%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-margin-bottom-small:40px;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-21 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">You Should Pay Attention to This<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-18 fusion-text-no-margin\" style=\"--awb-text-transform:none;\"><p>People with this tendency to colorectal cancer should be treated at a center that offers early detection.<\/p>\n<p>Regardless of the screening examinations, you should consult a doctor as soon as you experience gastrointestinal tract symptoms. These can be blood or mucus discharge from the bowel, stool abnormalities such as diarrhea or constipation, flatulence, or pain. However, non-specific signs such as weight loss should also be noticed and reported to a doctor so that colon cancer can be investigated.<\/p>\n<p>You should also consult a doctor if you have any other new abnormalities or complaints, e.g., abdominal pain, lower abdominal pain, or palpable lumps on the breast.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-36 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:11.52%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:5.76%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.6864%;--awb-spacing-left-medium:5.76%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-menu-anchor\" id=\"weitere-informationen\"><\/div><div class=\"fusion-title title fusion-title-22 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Further Information<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:10px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-19 fusion-text-no-margin\" style=\"--awb-text-transform:none;--awb-margin-bottom:20px;\"><ul>\n<li><a href=\"https:\/\/familienhilfe-polyposis.de\/\">Link to German website of\u00a0 &#8220;Familienhilfe Polyposis&#8221;<\/a><\/li>\n<\/ul>\n<p>Patients can also register for the <a href=\"https:\/\/www.krebs-praedisposition.de\/en\/cps-research\/cps-registry\/\">CPS registry<\/a> at any time or<a href=\"https:\/\/www.krebs-praedisposition.de\/en\/information-for-professionals\/patient-registration\/\"> have this done by their doctors in charge<\/a>.<\/p>\n<\/div><div class=\"fusion-title title fusion-title-23 fusion-sep-none fusion-title-text fusion-title-size-four\" style=\"--awb-margin-bottom-small:0px;--awb-margin-top-medium:0px;--awb-margin-bottom-medium:0px;\"><h4 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Any further questions?<\/h4><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:0px;margin-bottom:30px;width:100%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom13);border-color:var(--awb-custom13);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-20 fusion-text-no-margin\" style=\"--awb-text-transform:none;\"><p>You can reach us by e-mail and telephone, or you can come to our consultation hours in person. For more information, please visit <a href=\"https:\/\/www.krebs-praedisposition.de\/en\/contact-2\/\">our contact page<\/a>.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-27000","lexikon","type-lexikon","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.krebs-praedisposition.de\/en\/wp-json\/wp\/v2\/lexikon\/27000","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.krebs-praedisposition.de\/en\/wp-json\/wp\/v2\/lexikon"}],"about":[{"href":"https:\/\/www.krebs-praedisposition.de\/en\/wp-json\/wp\/v2\/types\/lexikon"}],"wp:attachment":[{"href":"https:\/\/www.krebs-praedisposition.de\/en\/wp-json\/wp\/v2\/media?parent=27000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}