Over months to years, the development of pigment changes (color changes of the skin with light spots = hypopigmentation or dark spots = hyperpigmentation), atrophy (thin skin), hypertrophy (thickened skin), and increased vascularity (telangiectasia), summarized under the term poikiloderma, which persists for life.<\/p>\n
\n- Skin changes (poikiloderma)<\/li>\n
- Thinning hair, eyebrows, eyelashes<\/li>\n
- Calluses, especially on the soles of the feet<\/li>\n
- Nail changes<\/li>\n
- Short stature<\/li>\n
- Gastrointestinal problems (nutritional disorders, chronic vomiting\/diarrhea)<\/li>\n
- Bone defects<\/li>\n
- Bone substance reduction (osteoporosis)<\/li>\n
- Dental abnormalities<\/li>\n
- Eye problems<\/li>\n
- Bone marrow failure<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>