The diagnosis is made clinically by an expert experienced in syndromes. The detection of a defect in the WT1 <\/em>gene confirms the diagnosis. The clinical signs are:<\/p>\nWAGR<\/strong>: W<\/strong>ilms’ tumor risk, a<\/strong>niridia(incomplete formation of the iris), urog<\/strong>enital malformation, mental r<\/strong>etardation<\/p>\nDDS<\/strong>: kidney disease (diffuse mesangial sclerosis, early kidney failure), genital malformations, maldevelopment of the gonads (gonads), Wilms tumor risk<\/p>\nFS<\/strong>: kidney disease (focal segmental glomerular sclerosis), maldevelopment of the gonads, genital malformations<\/p>\n<\/div><\/div><\/div><\/div><\/div>