{"id":27078,"date":"2024-05-23T16:33:42","date_gmt":"2024-05-23T14:33:42","guid":{"rendered":"https:\/\/www.krebs-praedisposition.de\/?post_type=lexikon&p=27078"},"modified":"2025-08-06T12:00:57","modified_gmt":"2025-08-06T10:00:57","slug":"pole-mutation","status":"publish","type":"lexikon","link":"https:\/\/www.krebs-praedisposition.de\/en\/lexikon\/pole-mutation\/","title":{"rendered":"POLE Mutation"},"content":{"rendered":"

\"POLE Mutation\" \u2013\u00a0What Is It?<\/h2><\/div>
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The POLE<\/em> mutation describes a genetic change in the POLE<\/em> gene. POLE <\/em>mutation carriers have an increased risk of developing multiple colon polyps, colon cancer, endometrial cancer, and possibly other types of cancer. In isolated cases, the POLE<\/em> mutation is the cause of FILS syndrome and IMAGE syndrome.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div>

Overview of the Chapters on This Page:<\/h4><\/div><\/div><\/div>