Dear families, dear colleagues,
We welcome you on our website for the Cancer Predisposition Syndrome Registry. Cancer predisposition syndromes (CPS) are genetic conditions associated with an increased cancer risk. CPS are especially relevant for children and adolescents with cancer. We are a team of scientists and pediatric oncologists. It is our aim to advance CPS research, together with affected individuals and their families other scientists and health professionals: through Facts, Investigation, and Therapy.
We are just beginning to understand the important role of CPS, especially in children affected by cancer. We would like to accelerate this process. In case you have questions related to CPS or if you wish to support our work, we are looking forward to receiving your message!
Christian P. Kratz, MD Stefan M. Pfister, MD
Our research projects
Genetic cancer predisposition is the most important known cause of childhood cancer. By launching the CPS-Registry, we would like to
We please you to support our work by reporting your patients to our registries as a treating physician. The CPS registry is open for all known cancer predisposition syndromes. Both children and adults can be registered.
About us – our teams in Hannover and Heidelberg
Hannover
Heidelberg
News about our scientific work
Incorrect fax number in our current consent and information documents
On our current consent and information documents, we have made a mistake regarding the fax number. We apologize very much for this circumstance! The incorrect fax number does not exist, so that no data protection problems will arise for you or your patients.
Start of the “Liquid Biopsy” project
Based on the Cancer Predisposition Syndrome Registry, the Liquid Biopsy project is now starting. The aim is to detect small DNA fragments of tumor cells in the blood. In the future, this will enable the early and least invasive detection of the development and process of malignant diseases.
Integration of FAR01 in LFS-CPS-R01
The Fanconi Anaemia Registry has been affiliated to the Cancer Predisposition Syndrome Registry since January 2020. This has significantly simplified the administrative structures. However, this does not change anything for the registered patients. A click on the picture above will take you to further information about the affiliation.
Competence in clinic and science
CPS-Outpatient clinic
If you or your child has been diagnosed with a cancer predisposition syndrome (CPS), you are welcome to come to our CPS-Outpatient clinic; especially if such an offer is not available in your area. Please ask your attending physicians in this regard.
To make an appointment with us, simply fill out the registration form and send it to us. We will contact you as soon as possible.
Registration at the CPS-Outpatient clinic
Research
Since 2017 we have been conducting the Registry for people with CPS. We are investigating questions relating to the development of cancer and asserving biospecimen. In this way, we create a resource that allows us to answer basic scientific questions. All information about our CPS-Registry, the Fanconi Anemia Registry and the two accompanying projects “Liquid Biopsy” and “ADDRess” can be found under the following links.
Further information
Recent Publications on CPS
Nearly Half of TP53 Germline Variants Predicted To Be Pathogenic in Patients With Osteosarcoma Are De Novo: A Report From the Children’s Oncology Group
This article, published in "Cancer Genetics", reports that a high proportion of rare pathogenic TP53 variants in the pediatric patients with osteosarcoma (OS) may be de novo. For further information click on the publication title.
“Mesenchymal Hamartoma of Liver and DICER1 Syndrome”
In this article, published in "The New England Journal of Medicine", a mesenchymal hematoma of the liver (MHL) was discovered in two children with DICER1 syndrome. MHL is a benign tumor in children that is characterized by, among other things, cystically dilated bile ducts. The data of this study suggest that MHL is a new phenotype of DICER1 syndrome. For further information click on the publication title.
“XAF1 as a modifier of p53 function and cancer susceptibility”
This article was published in the journal “SCIENCE ADVANCE” and reports on a newly discovered “modifier” of the p53 function of a variant and its possible influence on the cancer susceptibility of those affected. Please click on the publication title for more information.
