The Accompanying Project “Liquid Biopsy”

In recent years, the detection of cell-free DNA (cfDNA) in the blood has gained increasing importance. This circulating cfDNA contains fragments from both healthy and tumor cells. Analyzing this “liquid biopsy” aims to detect the early development and progression of malignancies with minimal invasiveness. Moreover, miRNA, methylation, and protein patterns in the blood can be detected through liquid biopsy. In the future, this form of liquid diagnostics could also be used for therapy monitoring and aftercare. Given the high cancer risk in individuals with cancer predisposition syndromes (CPS), this blood-based and less invasive method of cancer detection holds particular promise for CPS patients.

If you have any questions about the accompanying project “Liquid Biopsy”, you may find what you’re looking for in the quick links provided in the following section. Alternatively, feel free to contact us directly:

If you have any questions about the accompanying project “Liquid Biopsy”, you may find what you’re looking for in the quick links provided in the following section. Alternatively, feel free to contact us directly:

Registration Requirements

The Liquid Biopsy Project is an accompanying project to the Cancer Predisposition Syndrome Registry. Therefore, registration in the CPS registry is a prerequisite for participation in the Liquid Biopsy Project. In the first step, liquid biopsies are collected from patients with the following CPS:

  • Ataxia-Teleangiectasia
  • Beckwith-Wiedemann Syndrome – High Risk (UPDpat, IC1-GOM)
  • Bloom Syndrome
  • Costello Syndrome
  • Fanconi Anemia
  • Gorlin Syndrome
  • Constitutional Mismatch Repair Deficiency
  • Li-Fraumeni Syndrome
  • Neurofibromatosis Type 1
  • Nijmegen Breakage Syndrome
  • Rothmund-Thomson Syndrome
  • Xeroderma Pigmentosum

Implementation

Approximately 10 ml of blood should be collected every 6 months from patients with selected CPS. Special blood tubes provided by the CPS Registry 01’s registry center are required for the samples. These blood samples can be taken as part of another diagnostic or routine blood sample.

To identify the samples, they are labeled with the patient’s initials, quarter and year of birth, and then sent to the Registry Center in Hanover. Subsequently, the samples are pooled and sent to the DKFZ in Heidelberg for further analysis.

No clinical decisions will be made based on the research results, and patients will not be informed of the results of their blood tests, which will only be used to identify markers.

The aim of this research project is to enable the early and least invasive detection of malignant processes or their progression. By comparing with the early detection tests of CPS patients registered in the CPS Registry 01, conclusions can be drawn about, for example, the temporal relationship between markers measurable in the blood and the clinical occurrence of symptoms, radiological evidence of a tumor, or changes in other laboratory values. There is no direct personal benefit for patients participating in the research project.

Patient Registration for the Accompanying Project “Liquid Biopsy”

We are delighted when individuals living with a CPS decide to take part in the “Liquid Biopsy” accompanying project. There are two ways to do this:

As the attending physician, you register your patient for a liquid biopsy.

As the attending physician, you register your patient for a liquid biopsy.

Typically, the attending physician handles the registration for “Liquid Biopsy”. We explain how this registration process works in detail on the page: “Patient registration”. Clicking on this info box will take you there directly.

As a patient, you register yourself for a liquid biopsy.

As a patient, you register yourself for a liquid biopsy.

If the attending physician is unable to register for “Liquid Biopsy”, we also offer CPS patients the option of self-registration. You can find all further information on this on the page “CPS Research – Get Involved”. Clicking on this info box will take you there directly.

Das Team des Begleitprojektes “Liquid Biopsy”

  • Beatrice Hoffmann
    Beatrice Hoffmann
    Studienassistenz, Patientensupport
    Studienassistenz, Patientensupport
  • Anja Karow
    Anja Karow
    Projektmanagerin ADDRess
    Projektmanagerin ADDRess
  • Christina Reimer
    Christina Reimer
    Biologisch technische Assistentin
    Biologisch technische Assistentin
  • Birte Sänger
    Birte Sänger
    Studienassistenz, Patientensupport
    Studienassistenz, Patientensupport
  • Prof. Dr. med. Christian Kratz
    Prof. Dr. med. Christian Kratz
    Head of the CPS outpatient department and the CPS Registry
    Head of the CPS outpatient department and the CPS Registry
  • Beatrice Hoffmann
    Beatrice Hoffmann
    Studienassistenz, Patientensupport
    Studienassistenz, Patientensupport
  • Anja Karow
    Anja Karow
    Projektmanagerin ADDRess
    Projektmanagerin ADDRess
  • Christina Reimer
    Christina Reimer
    Biologisch technische Assistentin
    Biologisch technische Assistentin
  • Birte Sänger
    Birte Sänger
    Studienassistenz, Patientensupport
    Studienassistenz, Patientensupport
  • Prof. Dr. med. Christian Kratz
    Prof. Dr. med. Christian Kratz
    Head of the CPS outpatient department and the CPS Registry
    Head of the CPS outpatient department and the CPS Registry