Dear patients, dear parents!
Dear colleagues!
In recent years, the detection of cell-free DNA (cfDNA) in blood has become increasingly important. This circulating cfDNA in blood contains DNA fragments from healthy cells as well as from tumor cells. The analysis of this so-called liquid biopsy should make it possible to detect the development and progress of malignant processes at an early stage and with as little invasion as possible. In addition, patterns of miRNA, methylation and proteins can be detected in the blood as a part of liquid biopsies as well. In the future, it is conceivable that this form of liquid diagnostics will also be used for therapy monitoring and aftercare. Due to the high risk of cancer in people with cancer predisposition syndromes (CPS), this blood-based and less invasive form of cancer detection is particularly promising for CPS patients.
About the Liquid Biopsy project
Criteria for participation in the Liquid Biopsy project
Requirements for registration
The Liquid Biopsy project is a subproject of the Cancer Predisposition Syndrome Registry (CPS-Registry). Therefore, registration in the CPS-Registry is a prerequisite for participation in the Liquid Biopsy project. You will find all the necessary documents on the CPS-Registry page.
Initially, liquid biopsies should only be recorded in patients with the following CPS:
Registration in the Liquid Biopsy project by the treating physician
How to proceed
Please hand out the age-appropriate information to the patient and, if applicable, to the person with custody. This remains without signature with the patient/guardian.
Please hand out the age-appropriate informed consent to the patient and, if applicable, to the person with custody. This must be signed by the patient and, if applicable, the person with custody and the doctor providing the information.
Please carry out the blood collection as described below.
Please fill out the delivery form. The delivery form is provided in german language.
Then send us the blood with the delivery form to the following postal address:
Hannover Medical School
Department of Paediatric Haematology and Oncology
KPS-Register
OE 6780
Carl-Neuberg-Straße 1
D-30625 Hannover, GermanyPlease repeat the blood collection and shipment to us every 6 months.
Letters of information and consent as well as the delivery form for biospecimen can be found in the download area download area at the bottom of this page.
Registration in the Liquid Biopsy project by self-registration
How to registrate yourself or your child in the Liquid-Biopsy project
Please contact us to initiate the participation.
Please read the age-appropriate information carefully.
Please also read the age-appropriate declaration of consent carefully.
The information for the Liquid Biopsy project will then be given in a personal or telephone conversation with a physician from the CPS-Registry team. During this conversation we will explain the contents, questions and procedures of the project and answer your questions.
After the interview we will send you the declaration of consent already signed by the physician in duplicate. Please complete it with your name, place and date and sign it.
We will send you the necessary material for the blood collection. Please have a doctor take blood samples and send the blood together with the delivery form for biospecimen and a version of the completed and signed consent form to the following address:
Hannover Medical School
Department of Paediatric Haematology and Oncology, OE 6780
KPS-Register
Carl-Neuberg-Straße 1
D-30625 Hannover, GermanyBlood should be collected every 6 months. Please contact us to obtain the appropriate material.
Blood collection and delivery
The blood collection of patients with selected CPS (see above) should be done every six months. Approximately 10 ml of blood should be taken. The blood sample can be taken as part of another diagnostic or routine blood collection.
Special blood tubes (cf-DNA Preservative Tubes of the company NORGEN) are required for the collection. We will be happy to provide these tubes. Simply contact us for this.
| KPS-Register Department of Paeditric Haematology and Oncology Hannover Medical School Carl-Neuberg-Str. 1 D-30625 Hannover, Germany |
|
| +49 511 532-9408 or -6738 | |
| +49 511 532-161026 | |
| PAO.LFS-CPS@mh-hannover.de |
Downloadmaterial
In this section of our website you will find all the necessary documents to participate in the Liquid Biopsy project. Please note that different versions of the information and consent forms must be used for registration by the treating physician and for self-registration. If you have any questions regarding registration, please contact our documentation and laboratory team Beatrice Hoffmann, Birte Sänger or Christina Reimer directly.
Registration by the treating physician
Please always send blood together with the delivery form. You will find the address at the top of this page and on the delivery form.
Registration by self-registration
| Contact form | |
| +49 511 532-9408 oder -6738 | |
| +49 511 532-161026 | |
| PAO.LFS-CPS@mh-hannover.de | |
| Due to the current corona crisis, you can best contact us by e-mail or via our contact form. Thank you for your understanding! |
Please always send blood together with the delivery form. You will find the address at the top of this page and on the delivery form.
Contact persons
If you have any questions about the execution or shipment, please do not hesitate to contact us. You can contact us by telephone best in the morning.
We are gladly there for you!
Christina Reimer
Biologic Technical Assistent
| +49 511 532-7803 | |
| +49 511 532-161026 | |
| PAO.LFS-CPS@mh-hannover.de |
